Table 9.
Basal haemodynamic parameters in intact, anaesthetized cats prior to receiving bolus i.v. vehicle (1% DMSO in saline, v v−1) or 1 mg kg−1 GSK248451 and inhibition of arterial pressure × rate product over the recording period (35 min) immediately following U-II (1 nmol kg−1, i.v.) administration
| Vehicle-treated (1% DMSO in saline, v v−1) | GSK248451-treated (1 mg kg−1, i.v.) | |
|---|---|---|
|
Basal haemodynamic parameter | ||
| Mean arterial pressure (mmHg) |
70±6 |
69±7 |
| Systolic arterial pressure (mmHg) |
91±6 |
94±8 |
| Diastolic arterial pressure (mmHg) |
57±6 |
53±5 |
| Heart rate (min−1) |
183±12 |
197±15 |
| |
|
|
|
Arterial pressure × rate product (AUC)t=0–35 min | ||
| Mean (mmHg·min−1) |
1072±179 |
409±106* |
| Systolic (mmHg·min−1) |
1507±153 |
506±122** |
| Diastolic (mmHg·min−1) | 787±202 | 337±95 |
All values are mean±s.e.m. Statistical comparisons were performed by paired, two-tailed t-test where *P<0.05 and **P<0.01 compared to vehicle-treated cats.