Table 3.
Study Ib: high-dose sLPC is not organ protective in endotoxaemia
|
Group |
Organ injury or dysfunction parameter (mean±s.e.m.) |
||||
|---|---|---|---|---|---|
| Creatinine (μmol l−1) | AST (IU l−1) | ALT (IU l−1) | Lipase (IU l−1) | CK (IU l−1) | |
| Sham-Control |
20±1* |
183±32* |
57±7* |
13±2* |
294±59* |
| LPS-Control |
65±6 |
471±67 |
174±22 |
42±6 |
1519±201 |
| sLPC 10 mg kg−1 1 h |
41±6* |
253±31* |
100±10* |
16±4* |
703±139* |
| sLPC 30 mg kg−1 1 h | 58±8 | 527±79 | 246±24* | 40±9 | 1272±326 |
*
P<0.05 compared to LPS-Control by ANOVA followed by Dunnett's post hoc test.