Figure 1.

Changes in the concentration of 5-HT and density of [³H]-paroxetine labelled 5-HT uptake sites in the cerebral cortex, hippocampus and striatum of rats 1, 2, 4, 8 and 32 weeks after MDMA 12.5 mg kg⁻¹, i.p. administration at a room temperature of 22°C. Open bars represent saline-treated animals and filled bars represent MDMA-treated animals. Results shown as mean±s.e.m., n=5–14. Different from the corresponding saline group: ^* P<0.05, ^**P<0.01, ^***P<0.001. One-way ANOVA followed by Newman–Keuls test.