Table 1.
Plasma laboratory results and body weights at the end of the study
| Parameter (unit) | 5/6 NX (n=9) | 5/6 NX+BAY 58-2667 (n=9) | Sham OP (n=10) |
|---|---|---|---|
| Body weight (g) |
415.0±49.3* |
391.2±50.7* |
502.0±75.4 |
| AST (U/l) |
51.0±28.7 |
51.6±29.5 |
55.5±11.1 |
| ALT (U/l) |
33.5±14.1 |
46.3±22.0 |
40.8±9.8 |
| AP (U/l) |
77.6±21.4 |
95.4±28.7 |
88.7±11.0 |
| GLDH (U/l) |
14.4±14.7 |
10.1±10.4 |
11.4±11.6 |
| LDH (U/l) |
107.3±83.8 |
104.1±70.1 |
132.8±45.5 |
| CK (U/l) |
96.1±42.0 |
105.2±53.4 |
109.5±25.3 |
| Crea (μmol/l) |
209.3±110.1** |
97.8±29.0**,† |
51.7±2.4 |
| Urea (mmol/l) |
52.8±46.9** |
18.5±6.0**,† |
6.0±0.9 |
| Protein (g/l) |
55.0±5.0** |
54.4±2.7** |
65.7±1.7 |
| PRA (ng/ml/h) |
0.7±0.5** |
1.3±1.0* |
2.6±1.2 |
| ANP (pg/ml) |
487.3±162.1 |
346.6±160.8 |
319.0±162.8 |
| BNP (pg/ml) | 47.3±19.3** | 33.3±11.0*,(†) | 16.7±7.9 |
Abbreviations: AP=alkaline phosphatase; ALT=alanine amino transferase; ANP=atrial natriuretic peptide; AST=aspartate amino transferase; BNP=B-type natriuretic peptide; CK=creatine kinase; Crea=creatinin; GLDH=glutamate dehydrogenase; LDH=lactate dehydrogenase; PRA=plasma renin activity.
Values are given as mean±s.d.
*
P<0.05/0.001 versus Sham OP;
**
P<0.05/0.001 versus Sham OP;
†
P<0.05 versus 5/6 NX;
(†)
P=0.05 versus 5/6 NX.