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A schematic picture of the PMEL17 protein with domains and known mutations. The transmembrane (TM) protein PMEL17 has previously been shown to regulate hypopigmented phenotypes in mouse, chicken, dog, and zebrafish. The location of known mutations associated with hypopigmentation in these species are indicated. R740C in chicken (Dun) is at the same location as the R618C in the horse (Silver).
