TABLE 2.
EBNA-2-repressed genes
| Gene or gene producta | Gene IDb | Molecular or biological function(s) |
|---|---|---|
| A2A adenosine receptor (ADORA2A) | 135 | G protein-coupled receptor |
| Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) | 241 | Inflammatory response |
| CD24 | 934 | Humoral immune response/small cell lung carcinoma cluster 4 antigen |
| CD52 (CAMPATH-1 antigen) | 1043 | Target for antibody-based chemotherapy |
| CD79B | 974 | BCR associated, signal transduction |
| Chimerin (CHN2) | 1124 | Intracellular signaling cascade |
| DKFZP586A0522 protein (DKFZP586A0) | 25804 | |
| FCH and double SH3 domains 2 (FCHSD2) | 9873 | Adaptor for signal transduction |
| cDNA: FLJ23572 fis, clone LNG12403 (AK027225) | ||
| Major histocompatibility complex class II, DPa1 (HLA-DPA1) | 3113 | Antigen presentation |
| Immunoglobulin lambda-like polypeptide 1 (IGLL1) | 3543 | B-cell development/BCR signaling |
| Lysosome-associated multispanning membrane protein-5 (LAPTM5) | 7805 | B-cell differentiation |
| Lipin 1 (LPIN1) | 23175 | Adipocyte differentiation |
| Leucine zipper, putative tumor suppressor 1 (LZTS1) | 11178 | Transcription, negative regulation of cell cycle |
| MADS box transcription enhancer factor 2 (MEF2B) | 4207 | Regulation of transcription |
| Cyclic AMP-dependent protein kinase inhibitor g (PKIG) | 11142 | Negative regulation of protein kinase activity |
| Ras association (RalGDS/AF-6) domain family 2 (RASSF2) | 9770 | Neuropeptide signaling pathway |
| T-cell leukemia/lymphoma 1A (TCL1A) | 8115 | Cell growth and/or maintenance |
| Kell blood group precursor (XK) | 7504 | Membrane transport |
a
Genes that scored present before estrogen induction and were repressed at least twofold in BJABK3 and BL41K3 after estrogen induction.
b
Unique gene ID according to the NCBI. ID, identification number.