FIG. 1.

F9 is conserved throughout the Poxviridae. (A) Multiple amino acid sequence alignment of VACV F9 and orthologs from representatives of each poxvirus genus. The bar denotes the predicted transmembrane (TM) domain. Identical amino acids are shaded gray; invariant cysteines are white on a black background. Abbreviations: VAC, vaccinia virus (Orthopoxvirus); YAB, Yaba monkey tumor virus (Yatapoxvirus); MYX, myxoma virus (Leporipoxvirus); LSD, lumpy skin disease virus (Capripoxvirus); SPV, swinepox virus (Suipoxvirus); MCV, molluscum contagiosum virus (Molluscipoxvirus); FPV, fowlpox virus (Avipoxvirus); ORF, ORF virus (Parapoxvirus); MSV, Melanoplus sanguinipes entomopoxvirus (Entomopoxvirus B); AMS, Amsacta moorei entomopoxvirus (Entomopoxvirus B). (B) Sequence alignment of VACV WR F9 and L1 proteins. Identical amino acids are denoted as in panel A.