FIG. 2.
In vitro and in vivo characterization of MAD78 and TX02. (A) A549 cells were infected (MOI = 1) with TX02, MAD78, or NY 3356. At 2, 6, 18, 24, 48, and 69 h postinfection (TX02, NY 3356) or 2, 6, 16, 24, 48, and 72 h postinfection (MAD78), culture supernatants were collected and the titers of the viruses were determined by plaque assay on Vero cells. (B) Groups of wild-type C57BL/6 mice were infected by footpad inoculation with 102 PFU of MAD78 or TX02 and monitored for survival. Results are plotted as percent surviving mice.