FIG. 6.

JAK-STAT signaling controls WNV replication and virulence. (A) Wild-type (WT) and IFNAR^−/− MEFs were infected with TX02 or MAD78, and the viral supernatant titers were determined by plaque assay on Vero cells. Columns represent the increases (n-fold) in titers of viral supernatant from wild-type MEFs to IFNAR^−/− MEFs. **, P < 0.01; ***, P < 0.0001. (B) Groups of wild-type (WT) and congenic IFNAR^−/− C57BL/6 mice were inoculated subcutaneously with 10² PFU of TX02 or MAD78 and monitored for survival. Results are plotted as percent survival for each group. Symbols: wild type, TX02 (•); wild type, MAD78 (▪); IFNAR^−/−, TX02 (○); IFNAR^−/−, MAD78 (□).