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TABLE 3.

Antibody avidity indices of sera from individual monkeys immunized with combinations of the DENV-2 DNA, PIV, and recombinant vaccinesa

Vaccination group Monkey Antibody avidity indexb
Day 90 Day 210 challenge Day 28 postchallenge
DRR 942 19 25 26
898 16 39 63
WTV 39 49 33
XJX 33 31 40
GMT 25 35 38
DPP 992 27 53 57
VFE 33 43 80
VAP 26 50 42
XCW 33 57 73
GMT 30 50 61
DR/DR/DR A25 19 31 52
939 30 40 60
981 26 28 38
973 20 56 50
GMT 23 37 50
DP/DP/DP 975 19 33 55
895 41 53 52
921 33 35 55
JWK 45 37 47
GMT 33 39 52
RRR 999 17 43 28
C67 12 36 27
C51 13 30 29
B27 15 17 32
GMT 14 30 29
PPP A79 22 59 62
A43 40 63 85
A65 47 68 64
C49 33 67 91
GMT 34 64 75
DDD 931 30 33 55
GZ 25 47 53
F483 29 45 43
28R 40 40 39
GMT 30 41 47
PBS 887 c 3
CO7 6
923 6
B13 5
GMT 5
a

D, DNA vaccine; P, PIV; R, recombinant vaccine.

b

Avidity index = (OD405 after NASCN treatment)/(OD405 without NASCN treatment) × 100.

c

—, no DEN-specific antibody was detectable.