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Titers of wild-type, 22/n199, and 22/n199R viruses in tear film during the first 3 h postinoculation. Eight mice per group were infected; both eyes were swabbed at 30, 60, 90, 120, and 180 min pi with a single cotton-tipped applicator; and the titer of infectious virus was determined as described in the legend to Fig. 1. The average tear film titers from eight mice are shown, and error bars represent the standard deviations.
