FIG. 4.

Phenotype of CBL cultures (donor 1749) infected with herpesvirus saimiri C488 (C488 wt) and recombinant viruses carrying wild-type sequences (M11 wt) or mutations within the Tip reading frame (ΔCSKH, mSH3B, and ΔCSKH mSH3B). (A) Morphology documented by photography 5 weeks postinfection (no virus, C488 wt, and M11 wt as in reference 35). (B) Surface expression of CD3, CD4, and CD8 antigens 6 weeks after infection. The histograms show fluorescence intensity in logarithmic scale on the x axis and cell numbers in linear scale on the y axis. The open graphs represent negative isotype controls, and the solid graphs represent specific staining.