FIG. 7.

T-cell transformation assay with reconstituted herpesvirus saimiri wild-type (wt) and the virus expressing Tip with a mutation at position 127 (Y127F). Stimulated human CBL from 10 different donors were infected, and proliferation in the presence or absence of IL-2 was monitored by automated cell counting. An experiment was considered successful when viable cells were still present 15 weeks after infection when total cell numbers were determined as outlined in Materials and Methods. Diamonds, cell numbers of individual samples; horizontal lines, geometrical mean values.