Table 3.
Odds Ratios and 95% confidence intervals CI for developing cancer of the cervix in relation to genotypes considered as high or low producers of 1. -1082 IL-10 and 2. +874 IFN-γ.
| Cytokine | Race | *Genotype | CaCx n (%) | Controls n (%) | OR1 (95% CI) | OR2 (95% CI) | OR3 (95% CI) |
| 1. IL-10 | All# | n = 117 | n = 117 | ||||
| GG | 29 (25) | 41 (35) | 0.6(0.3–1.0) | 0.5(0.2–1.0) | 0.6(0.3–1.2) | ||
| AA | 88 (75) | 76 (64) | 1.0 | 1.0 | 1.0 | ||
| 2. IFN-γ | All# | n = 165 | n = 299 | ||||
| TT | 19 (12) | 33 (11) | 1.2(0.6–2.2) | 3.7(1.2–11.0) | 1.1(0.5–2.7) | ||
| AA | 146 (88) | 266 (89) | 1.0 | 1.0 | 1.0 | ||
| Mixed | n = 99 | n = 184 | |||||
| TT | 14 (14) | 26 (14) | 1.0(0.5–2.2) | 3.7(0.9–15.6) | 1.5 (0.4–4.8) | ||
| AA | 85 (86) | 158 (86) | 1.0 | 1.0 | 1.0 | ||
| African | n = 66 | n = 109 | |||||
| TT | 5 (8) | 7 (6) | 1.6 | 3.2(0.6–18.0) | 0.8(0.2–4.2) | ||
| AA | 61 (92) | 102 (94) | (0.4–6.3) 1.0 | 1.0 | 1.0 | ||
#All = Mixed race and African population groups (As there were no differences in the distribution of IL-10 alleles between the two South African ethnic populations, the data was combined) *Genotype = (TT and GG associated with high cytokine secretion and the AA associated with low cytokine secretion) OR1 =crude odds ratio (high secreting allele vs low secreting allele) OR2 = crude odds ratios, IFN-γ data adjusted for IL-10 and IL-10 data adjusted for IFN-γ OR3 = fully adjusted for ethnic group, 5 year age group, education, age at first sex, number of sexual partners, urban/rural living, number of pap smears, injectable/oral contraceptive use, smoking, parity and IFN-γ data adjusted for IL-10 and IL-10 data adjusted for IFN-γ