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. 2006 Sep 21;25(20):4971–4982. doi: 10.1038/sj.emboj.7601342

Figure 7.

Figure 7

Administering PSD-95(1–54) peptide reduces NMDAR-mediated synaptic currents. Left: traces of representative averaged mEPSCs or NMDAR components (INMDA; inset) obtained at 2 or 20 min after breakthrough with control intracellular solution (ICS) or ICS supplemented with GST alone or GST-PSD-95(1–54) in the recording pipette. Scale bars for mEPSCs are 25 pA/100 ms. Right: mean (±s.e.m.) changes in the NMDAR and AMPAR components of averaged mEPSCs recorded at 20 min after breakthrough expressed as a percentage of control mEPSCs obtained 2 min after breakthrough during recordings with control ICS (n=10 cells), GST alone (n=8 cells) or GST-PSD-95(1–54) (n=20 cells) (**P<0.01, t-test versus control ICS or versus GST alone).