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Knockdown of Mdm2 prevents endogenous GRK2 protein accumulation in response to IGF-1.Wild-type (A) and Mdm2-deficient MEFs (B) were treated with IGF-1 or vehicle for the indicated times as in Figure 7. GRK2 protein levels were determined by Western blot analysis and normalized by actin expression. Data are mean±s.e.m. of four experiments performed in triplicate, *P<0.05, **P<0.01.
