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Myelination of the developing corpus callosum is more extensive in the Hes5−/− mutant mice. Immunohistochemistry of coronal cryosections from p11 mice stained with antibodies against PLP, CNPase or MBP showed increased intensity of myelin protein staining in white matter tracts of the striatum (st) and in the anterior corpus callosum (cc) of Hes5−/− mice compared to Hes5+/+ controls (Scale bar=100 μm).
