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. 2006 Sep 21;25(20):4983–4995. doi: 10.1038/sj.emboj.7601349

Figure 5.

Figure 5

The C-terminal A-like domain is responsible for the effect of SPIN90/WISH on spinogenesis. (A, B) Neurons were transfected with GFP alone, GFP-SPIN90/WISH-ΔALD or GFP-SPIN90/WISH-ALD and visualized at 17DIV by immunofluorescence staining for GFP. High-magnification views are of the regions enclosed in rectangles. Images are inverted for clarity. The average number of spines per μm was analyzed (0.41±0.01, n=7 for GFP control; 0.32±0.01, n=8 for SPIN90-ΔALD-GFP; 0.39±0.01, n=6 for SPIN90/WISH-ALD; **P<0.05 by ANOVA and Tukey's HSD post hoc test). Scale bars, low magnification: 20 μm, high magnification: 5 μm.