TABLE 2.
In vitro activities of macrolides and telithromycin against 186 S. pneumoniae isolates according to genetic resistance factors
| Isolate and antibiotic | MIC (μg/ml)a
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| erm(B) and mef(A) negative isolates (n = 21) | |||
| Erythromycin | 0.016-1 | 0.032 | 0.125 |
| Azithromycin | 0.064-4 | 0.064 | 0.5 |
| Josamycin | 0.125-0.5 | 0.125 | 0.25 |
| Telithromycin | ≤0.008-0.064 | 0.016 | 0.032 |
| erm(B) positive and mef(A) negative isolates (n = 165) | |||
| Erythromycin | 1->128 | 64 | >128 |
| Azithromycin | 1->128 | >128 | >128 |
| Josamycin | 0.5->128 | 32 | >128 |
| Telithromycin | ≤0.008-2 | 0.064 | 0.25 |
a
50% and 90%, MICs at which 50 and 90% of isolates are inhibited, respectively.