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Comparison between regimens for gemifloxacin pharmacokinetic parametersa
| Parameter | Comparison | Point estimate | 95% confidence interval |
|---|---|---|---|
| AUC∞ (μg · h/ml) | B:A | 0.93 | 0.78-1.10 |
| C:A | 0.79 | 0.66-0.93 | |
| D:A | 0.95 | 0.80-1.13 | |
| Cmax (μg/ml) | B:A | 0.93 | 0.71-1.22 |
| C:A | 0.83 | 0.63-1.08 | |
| D:A | 1.03 | 0.79-1.35 |
Regimen abbreviations: A, gemifloxacin alone; B, gemifloxacin 2 h after calcium; C, gemifloxacin simultaneously with calcium; D, gemifloxacin 2 h before calcium.
