TABLE 1.

Effects of variations in medium and inoculum on control OD and caspofungin MIC data for eight isolates each of Candida spp. and A. fumigatus^a

Medium	pH	Inoculum (CFU/ml)	Mean ± SD control OD		No. of isolates for which ODs were <0.150		IC50 (μg/ml)				IC80 (μg/ml)
							Candida spp.		A. fumigatus		Candida spp.		A. fumigatus
			Candida spp.	A. fumigatus	Candida spp.	A. fumigatus	Range	Gmeanb	Range	Gmean	Range	Gmean	Range	Gmean
AM3	5.0	2 × 103	0.339 ± 0.115	1.165 ± 0.224	0	0	0.016-4.0	0.23	0.063-0.25	0.19	0.063-4.0	0.33	0.25-4.0	0.59
		2 × 104	0.326 ± 0.050	1.279 ± 0.256	0	0	0.063-4.0	0.33	0.016-0.25	0.11	0.063->16	1.01	0.063-16	1.20
		2 × 105	0.393 ± 0.064		0		0.063-4.0	0.55			0.063->16	0.93
	7.0	2 × 103	0.215 ± 0.054	0.903 ± 0.312	1	0	0.063-2.0	0.28	0.13-1.0	0.20	0.063-2.0	0.41	0.13->32	1.10
		2 × 104	0.276 ± 0.049	1.244 ± 0.312	0	0	0.016-2.0	0.28	0.016-0.13	0.059	0.063-2.0	0.39	0.016-16	0.78
		2 × 105	0.330 ± 0.077		0		0.016-4.0	0.33			≤0.032-4.0	0.39
MH	7.0	2 × 103	0.249 ± 0.061	1.686 ± 0.441	0	0	0.016-4.0	0.35	0.063-0.25	0.16	0.25-4.0	0.59	0.13-0.5	0.27
		2 × 104	0.278 ± 0.055	1.519 ± 0.571	0	0	0.13-4.0	0.47	0.016-0.25	0.12	0.25-4.0	0.77	0.13-1.0	0.28
		2 × 105	0.488 ± 0.369		0		0.063-4.0	0.60			0.063-4.0	0.60
RPMI 1640	5.0	2 × 103	0.673 ± 0.208	0.033 ± 0.024	0	8	0.25->16	1.4			0.25->16	2.38
		2 × 104	0.819 ± 0.165	0.058 ± 0.073	0	7	0.25->16	2.0			0.5->16	5.66
		2 × 105	0.851 ± 0.154		0		0.25->16	2.4			0.25->16	4.00
	7.0	2 × 103	0.782 ± 0.135	0.243 ± 0.083	0	0	0.25-8.0	1.2	0.25->16	1.41	0.25-8.0	1.54	1->16	13.5
		2 × 104	0.892 ± 0.116	0.313 ± 0.131	0	1	0.25-16	1.7	0.13-1.0	0.46	0.5->16	4.00	2->16	19.5
		2 × 105	0.915 ± 0.084		0		0.25-16	1.4			0.25->16	2.00
SAB	5.2	2 × 103	1.185 ± 0.278	3.188 ± 0.396	0	0	0.063-2.0	0.25	0.13-1.0	0.39	0.13-8.0	0.55	0.25-2.0	0.65
		2 × 104	1.325 ± 0.090	3.263 ± 0.095	0	0	0.063-2.0	0.36	0.13-0.25	0.19	0.13-16	0.93	0.25-0.5	0.28
		2 × 105	1.295 ± 0.096		0		0.13-16	1.0	0.13		0.13-16	1.01

^a The test plates were incubated for 48 h at 35°C.

^bGmean, geometric mean.