TABLE 2.
Ranges of caspofungin IC50 and IC80s for eight isolates each of Candida spp. and A. fumigatus determined in six different media and with two or three different starting fungus concentrationsa.
| Isolate | Range IC50 (μg/ml) | No. of dilnsb | Mode IC50 (μg/ml) | Range IC80 (μg/ml) | No. of dilns | Mode IC80 (μg/ml) |
|---|---|---|---|---|---|---|
| C. krusei ATCC 6258 | 0.016-2.0 | 7 | 0.25 | 0.063-2.0 | 5 | 0.25 |
| C. parapsilosis ATCC 22019 | 0.25-2.0 | 3 | 0.50 | 0.25->16 | 7 | 0.50 |
| C. albicans B59630 | ≤0.032-0.50 | 5 | 0.063 | ≤0.032->16 | 11 | 0.063 |
| C. albicans J990578 | 0.063->16 | 9 | 0.25 | 0.25->16 | 7 | 0.25 |
| C. albicans NR2 | 0.25-4.0 | 4 | 0.50 | 0.5->16 | 6 | 0.50 |
| C. albicans NR3 | 1.0-8.0 | 3 | 4.0 | 2->16 | 4 | 2.0 |
| C. albicans T25 | 2.0->16 | 4 | 4.0 | 2->16 | 4 | 4.0 |
| C. glabrata J981216 | 0.063-1.0 | 4 | 0.13 | 0.063-1.0 | 4 | 0.13 |
| A. fumigatus J980659 | 0.063-1.0 | 4 | 0.25 | 0.5->16 | 6 | 0.50 |
| A. fumigatus J980561 | 0.063-0.50 | 3 | 0.25 | 0.13-2.0 | 4 | 0.25 |
| A. fumigatus J970398 | ≤0.032->16 | 11 | 0.13 | 0.13->16 | 8 | 0.25 |
| A. fumigatus J970377 | 0.063-2.0 | 5 | 0.25 | 0.25->16 | 7 | >16 |
| A. fumigatus J960180 | 0.016-0.25 | 4 | 0.016 | ≤0.032-1.0 | 6 | 0.25 |
| A. fumigatus J960330 | 0.13-0.50 | 2 | 0.13 | 0.13->16 | 8 | 0.25 |
| A. fumigatus J940362 | ≤0.032-1.0 | 6 | 0.25 | 0.13->16 | 8 | 0.25 |
| A. fumigatus J931199 | 0.063->16 | 9 | 0.13 | 0.25->16 | 7 | 0.25 |
a
See Table 1.
b
No. of dilns, number of twofold dilutions between extremes of range.