TABLE 3.
Multivariate analysis of effects of performance variables on control growth OD and MIC (IC50 and IC80) for 13 isolates of Candida spp. and 8 isolates of A. fumigatus
| Isolate | Control OD
|
No. of isolates for which OD was <0.100 | Significant variablesa | IC50 (μg/ml)
|
Significant variable(s)a | IC80 (μg/ml)
|
Significant variable(s)a | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Range | Median | Range | Gmeanb | Range | Gmean | |||||
| C. albicans B59630 | 0.279-1.558 | 0.629 | 0 | M, G | 0.016-16 | 0.096 | M, G | 0.016->16 | 2.5 | G |
| C. albicans J981364 | 0.422-1.555 | 0.923 | 0 | G, T | 0.063->16 | 0.24 | M, G | 0.063->16 | 2.6 | G |
| C. albicans J981371 | 0.461-1.569 | 0.909 | 0 | G, T | ≤0.032->16 | 0.24 | M, G, I | 0.063->16 | 4.6 | M, G |
| C. albicans J990578 | 0.391-1.472 | 0.701 | 0 | M, G | 0.063->16 | 0.77 | G, I, H | ≤0.016->16 | 9.7 | G, I |
| C. albicans NR2 | 0.220-1.536 | 0.563 | 0 | M, G | 0.13->16 | 2.2 | M, I, T | 0.13->16 | 8.4 | M, G, T |
| C. albicans NR3 | 0.218-1.544 | 0.528 | 0 | M, G | 1.0->16 | 3.5 | M, G, I, T | 1.0->16 | 9.0 | G, T |
| C. albicans NR4 | 0.343-1.514 | 0.813 | 0 | M, G | 0.063->16 | 2.4 | M, G, I, T | 0.50->16 | 7.3 | G, T |
| C. albicans T25 | 0.272-1.429 | 0.556 | 0 | M, G | 2.0->16 | 9.3 | M, I, T, H | 4.0->16 | 17 | M, G |
| C. albicans T26 | 0.315-1.433 | 0.668 | 0 | M, G, I | 2.0->16 | 8.4 | M, I, T, H | 2.0->16 | 16 | G, I, T |
| C. albicans T28 | 0.346-1.385 | 0.614 | 0 | M, G | 0.063->16 | 0.55 | M, I, H | 0.25->16 | 7.8 | G, I, H |
| C. albicans T32 | 0.369-1.459 | 0.752 | 0 | M, G | ≤0.032->16 | 0.51 | M, G, H | 0.063->16 | 6.0 | M, G |
| C. glabrata J981216 | 0.210-1.714 | 0.726 | 0 | M, G | 0.063-0.50 | 0.16 | M, G | 0.063-1.0 | 0.28 | M, G |
| C. krusei ATCC 6258 | 0.163-1.676 | 0.520 | 0 | M, G, H | 0.13-1.0 | 0.25 | M, I, H | 0.13->16 | 0.90 | M, G |
| C. parapsilosis ATCC 22019 | 0.195-1.447 | 0.471 | 0 | M, G, H | 0.13-2.0 | 0.44 | M, G, I, H | 0.25->16 | 2.9 | G, T |
| A. fumigatus J931199 | 0.105-3.748 | 0.817 | 0 | T, H | 0.063->16 | 0.8 | I, H | 0.13->16 | 5.7 | M |
| A. fumigatus J940362 | 0.087-3.990 | 0.809 | 5 | T, H | 0.063->16 | 0.8 | T, H | 0.13->16 | 5.6 | M |
| A. fumigatus J960180 | 0.101-3.990 | 0.937 | 0 | T, H | ≤0.032->16 | 1.0 | T, H | 0.13->16 | 4.6 | M |
| A. fumigatus J960330 | 0.085-3.644 | 0.552 | 6 | T, H | ≤0.032->16 | 1.3 | M, H | 0.063->16 | 5.5 | M |
| A. fumigatus J970377 | 0.103-3.990 | 0.737 | 0 | M, T, H | ≤0.032->16 | 1.3 | M, H | 0.13->16 | 6.6 | M, T |
| A. fumigatus J970398 | 0.089-3.304 | 0.582 | 3 | T, H | ≤0.032->16 | 1.5 | M, H | 0.13->16 | 5.8 | M |
| A. fumigatus J980561 | 0.033-3.990 | 0.553 | 7 | T, H | ≤0.032->16 | 0.9 | H | 0.13->16 | 4.1 | M |
| A. fumigatus J980659 | 0.106-3.976 | 0.783 | 0 | G, T, H | 0.13->16 | 1.3 | T, H | 0.13->16 | 7.3 | M |
a
G, glucose concentration; I, initial cell concentration; M, growth medium; S, plates sealed with sticker; T, incubation temperature; H, incubation time. For inclusion in the table, the variable must have been shown to be a significant contributor to OD or MIC variation by ANOVA at the level of P < 0.01.
b
Gmean, geometric mean.