TABLE 4.
IC50s and IC80s of caspofungin for 22 fungal isolates in AM3 medium from three different suppliersa
| Isolate | AM3 from Difco
|
AM3 from Oxoid
|
AM3 from VWR
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 48 h
|
72 h
|
48 h
|
72 h
|
48 h
|
72 h
|
|||||||
| IC50 (μg/ml) | IC80 (μg/ml) | IC50 (μg/ml) | IC80 (μg/ml) | IC50 (μg/ml) | IC80 (μg/ml) | IC50 (μg/ml) | IC80 (μg/ml) | IC50 (μg/ml) | IC80 (μg/ml) | IC50 (μg/ml) | IC80 (μg/ml) | |
| C. albicans B59630 | 0.5 | 0.5 | 1 | 1 | 0.5 | 1 | 1 | 1 | 0.5 | 0.5 | 0.5 | 1 |
| C. albicans J981309 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.5 |
| C. albicans J981364 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 1 | 0.5 | 0.5 | 0.5 | 1 |
| C. albicans J981371 | 0.5 | >16 | 0.5 | 0.5 | 0.5 | 1 | 0.5 | 1 | 0.5 | 0.5 | 1 | 2 |
| C. albicans J990578 | 0.5 | >16 | 1 | 1 | 0.5 | 0.5 | 1 | 2 | 1 | 1 | 1 | 1 |
| C. albicans NR2 | 2 | 4 | 2 | 4 | 2 | 2 | 4 | 4 | 4 | 8 | 2 | 8 |
| C. albicans NR3 | 4 | 4 | 4 | 8 | 2 | 4 | 4 | 4 | 2 | 4 | 4 | >16 |
| C. albicans T25 | 8 | 8 | 8 | 8 | 4 | 4 | 4 | 4 | 4 | 8 | 8 | 8 |
| C. albicans T26 | 8 | 8 | 4 | 8 | 4 | 4 | 1 | 4 | 4 | 8 | 4 | 8 |
| C. albicans T28 | >16 | >16 | 2 | 2 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 2 |
| C. albicans T32 | >16 | >16 | 1 | 1 | 1 | 1 | 1 | 1 | 0.5 | 0.5 | 1 | 1 |
| C. glabrata J981216 | 0.5 | 0.5 | 0.5 | 1 | 0.5 | 0.5 | 1 | 1 | 0.5 | 0.5 | 2 | 2 |
| C. krusei ATCC 6258 | 0.5 | 0.5 | 0.5 | 1 | 0.5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| C. parapsilosis ATCC 22019 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| A. fumigatus J931199 | 0.5 | 8 | 1 | 8 | 1 | 4 | 1 | 2 | 1 | 4 | 1 | 8 |
| A. fumigatus J940362 | 1 | 2 | 1 | 4 | 2 | 4 | 1 | 8 | 1 | 2 | 4 | 4 |
| A. fumigatus J960180 | 0.5 | 4 | 1 | 8 | 1 | 1 | 1 | 2 | 0.5 | 8 | 2 | >16 |
| A. fumigatus J960330 | 0.5 | 8 | 1 | 2 | 0.5 | 1 | 1 | 4 | 1 | 1 | 1 | 1 |
| A. fumigatus J970377 | 1 | 16 | 1 | >16 | 1 | >16 | 1 | >16 | 1 | 2 | 16 | >16 |
| A. fumigatus J970398 | 0.5 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0.5 | 1 | 1 | 1 |
| A. fumigatus J980561 | 0.5 | 2 | 0.5 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| A. fumigatus J980659/3 | 1 | >16 | 1 | >16 | 0.5 | >16 | 1 | >16 | 1 | 1 | 1 | >16 |
a
The endpoints were read after 48 and 72 h of incubation.