TABLE 4.
Organ colony counts from a series of experiments
| Expt no.b | Group | Dose (mg/kg)
|
Colony count (mean log10 CFU/g ± SD)a
|
|||
|---|---|---|---|---|---|---|
| AMB | Mycograb | Kidney | Liver | Spleen | ||
| 1 | 1 | 0.6 | 2 | (9)e | (9)d | (9)d |
| 2 | 0.6 | 0.2 | (10)e | (10)d | (9)d | |
| 3 | 0.6 | b3.66 ± 0.82 (4) | (9)d | (10)d | ||
| 4 | 2 | b4.58 ± 0.76 (2) | b3.50 ± 0.47 (3) | b3.12 ± 0.11 (4) | ||
| 5 | 0.2 | 5.1 ± 0.11 (0) | 3.85 ± 0.81 (3) | 3.35 ± 0.33 (3) | ||
| 6 | 5.5 ± 0.5 (0) | 4.42 ± 0.59 (2) | 3.65 ± 0.69 (2) | |||
| 2 | 1 | 0.6 | 2 | (9)d | (9)d | (8)d,e |
| 2 | 0.6 | 0.2 | (9)d | (8)d | 3.71 ± 0.64 (4) | |
| 3 | 0.6 | (9)d | (7) | b4.18 ± 0.22 (2) | ||
| 4 | 2 | (6) | b4.32 ± 0.82 (4) | b3.87 ± 0.93 (1) | ||
| 5 | 0.2 | (6) | b4.35 ± 0.26 (4) | b3.81 ± 0.78 (1) | ||
| 6 | 4.05 ± 0.1 (0) | 5.15 ± 0.18 (0) | 4.81 ± 0.33 (0) | |||
| 3 | 1 | 0.6 | 2 | (9)d | (6) | (8)d,e |
| 2 | 0.6 | 0.2 | (10)d | (6) | (8)d,e | |
| 3 | 0.6 | (9)d | b4.74 ± 1.0 (2) | b4.24 ± 0.25 (3) | ||
| 4 | 2 | (8)d | b5.54 ± 0.18 (0) | b5.19 ± 0.31 (0) | ||
| 5 | 0.2 | 5.17 ± 0.19 (2) | b6.01 ± 0.25 (0) | 5.30 ± 0.39 (0) | ||
| 6 | 5.19 ± 0.90 (0) | 6.57 ± 0.34 (0) | 5.86 ± 0.76 (0) | |||
| 4 | 1 | 0.6 | 2 | (8)d | (10)d | (10)d |
| 2 | 0.6 | 0.2 | (8)d | (10)d | (10)d | |
| 3 | 0.6 | (8)d | (10)d | (10)d | ||
| 4 | 2 | b4.24 ± 0.95 (1) | (9)d | (10)d | ||
| 5 | 0.2 | b4.41 ± 0.72 (1) | (10)d | (10)d | ||
| 6 | 5.30 ± 0.13 (0) | 3.82 ± 0.69 (1) | 4.41 ± 0.93 (3) | |||
| 5 | 1 | 0.6 | 2 | 3.82 ± 0.81 (4) | (10)d,e | (10)d,e |
| 2 | 0.6 | 0.2 | 3.84 ± 0.78 (1) | (9)d | 3.89 ± 0.94 (2) | |
| 3 | 0.6 | 4.01 ± 0.93 (1) | 3.08 ± 0.12 (5) | 4.10 ± 0.98 (0) | ||
| 4 | 2 | 4.01 ± 0.92 (1) | (9)d | 4.03 ± 0.33 (2) | ||
| 5 | 0.2 | 4.01 ± 0.09 (3) | (9)d | 4.07 ± 0.31 (3) | ||
| 6 | 4.00 ± 0.04 (0) | 3.54 ± 0.65 (3) | 4.05 ± 0.08 (0) | |||
| 6 | 1 | 0.6 | 2 | b4.56 ± 0.81 (0) | b3.66 ± 0.25 (4) | b4.08 ± 0.02 (2) |
| 2 | 0.6 | 0.2 | b4.48 ± 0.34 (0) | b4.09 ± 0.27 (2) | b4.11 ± 0.29 (1) | |
| 3 | 0.6 | b4.62 ± 0.94 (0) | b3.98 ± 0.06 (3) | b4.24 ± 0.29 (2) | ||
| 4 | 2 | b4.60 ± 0.65 (0) | b4.07 ± 0.26 (3) | b4.32 ± 0.31 (1) | ||
| 5 | 0.2 | b4.77 ± 0.79 (0) | b4.28 ± 0.28 (0) | b4.48 ± 0.38 (2) | ||
| 6 | 5.66 ± 0.64 (0) | 5.31 ± 0.44 (0) | 5.24 ± 0.16 (0) | |||
a
Number of negative biopsy specimen in parentheses.
b
Experiments: 1, FLC-resistant C. albicans; 2, C. krusei; 3, C. glabrata 4, C. tropicalis; 5, C. parapsilosis; 6, C. parapsilosis (clinical isolate).
c
Statistically significant (Scheffe's test, P < 0.05) versus the control group 6.
d
Statistically significant number of negative biopsy specimens (Fisher's exact test, P < 0.05) versus the control group 6.
e
Statistically significant numbers of negative biopsy specimens (Fisher's exact test, P < 0.05) versus the AMB-treated group 3.