Table 3.

Most abundant CB regions in Human and their significant functional associations and predicted protein disorder (*)

Bias	Number of members	Mean disorder (D) value	Functional categories (GO term [# of occurrences]; description; P' value)
{P}	273	0.61	GO:0005737 [55]; cytoplasm (3 × 10-23)
			GO:0007155 [28]; cell adhesion (4 × 10-10)
{C}	183	0.00	GO:0005515 [37]; protein-binding (2 × 10-4)
			GO:0005509 [35]; calcium-ion binding (3 × 10-15)
			GO:0007155 [29]; cell adhesion (5 × 10-16)
			GO:0005198 [27]; structural-molecule activity (4 × 10-16)
			GO:0046872 [21]; metal-ion binding (4 × 10-3)
			GO:0005578 [16]; extracellular matrix (sensu Metazoa) (8 × 10-9)
{GP}	116	0.76	GO:0005737 [65]; cytoplasm (2 × 10-61)
			GO:0007155 [27]; cell adhesion (2 × 10-19)
			GO:0005198 [12]; structural-molecule activity (2 × 10-3)
			GO:0005578 [9]; extracellular matrix (sensu Metazoa) (8 × 10-3)
{Q} †	77	0.41	GO:0005634 [34]; nucleus (3 × 10-8)
			GO:0006355 [21]; DNA-dependent regulation of transcription (1 × 10-4)
{S}	74	0.71
{G}	70	0.40	GO:0005634 [24]; nucleus (2 × 10-2)
{E}	69	0.49	GO:0005198 [10]; structural-molecule activity (1 × 10-3)
{ED} †	33	0.56	GO:0005634 [24]; nucleus (1 × 10-11)
			GO:0006355 [14]; DNA-dependent regulation of transcription (6 × 10-5)
{PG}	32	0.75
{QP} †	30	0.52

(*) – The CB regions are sorted in decreasing order of abundance. They are denoted by their CB signatures in column #1. Column #2 contains the total number of members in a particular cluster; column #3 is the mean value of D, the disorder fraction of each member; column #4 lists the top five significantly-associated (P' ≤ 0.05, adjusted for multiple hypothesis testing) GO (Gene Ontology terms for the cluster in the format: GO term name [count for GO term]; description of GO term in words. In addition, bias types that are significantly associated with transcription (where we reduced GO categories to just two categories, 'transcription-related' and 'non-transcription-related'), are labelled with a † sign.