Table 4.

Top Ten Biases for Fruitfly, and their significant functional associations and protein disorder values (*)

Bias	Number of members	Mean disorder (D) value	Functional categories (GO term [# of occurrences]; description; P' value)
{Q} †	274	0.45	GO:0005634 [78]; nucleus (2 × 10-14)
			GO:0006357 [53]; regulation of transcription from RNA polymerase II promoter (1 × 10-16)
			GO:0003700 [44]; transcription factor activity (3 × 10-12)
			GO:0003677 [37]; DNA binding (7 × 10-6)
			GO:0005515 [33]; protein binding (8 × 10-3)
			GO:0003704 [20]; specific RNA polymerase II transcription factor activity (2 × 10-5)
{QH} †	187	0.81	GO:0005634 [75]; nucleus (2 × 10-24)
			GO:0003700 [52]; transcription factor activity (3 × 10-27)
			GO:0006357 [45]; regulation of transcription from RNA polymerase II promoter (9 × 10-18)
			GO:0008270 [36]; Zn-ion binding (9 × 10-12)
			GO:0003677 [35]; DNA binding (1 × 10-9)
			GO:0006355 [30]; DNA-dept. regulation of transcription (3 × 10-13)
			GO:0003702 [29]; RNA polymerase II transcription factor activity (4 × 10-16)
			GO:0045449 [26]; regulation of transcription (6 × 10-15)
			GO:0007498 [22]; mesoderm development (1 × 10-7)
{C}	70	0.00	GO:0005198 [25]; structural molecule activity (2 × 10-27)
			GO:0007165 [23]; signal transduction (5 × 10-14)
			GO:0016337 [19]; cell-cell adhesion (1 × 10-19)
			GO:0005886 [14]; plasma membrane (1 × 10-3)
			GO:0005102 [14]; receptor binding (6 × 10-9)
{P}	62	0.13
{T}	61	0.28
{N}	58	0.45	GO:0005634 [19]; nucleus (3 × 10-2)
			GO:0003729 [16]; mRNA binding (1 × 10-7)
			GO:0003723 [16]; RNA binding (1 × 10-11)
{G}	50	0.14
{H}	44	0.42
{S}	38	0.25
{A} †	38	0.21	GO:0005634 [16] nucleus (3 × 10-3)
			GO:0006357 [14]; regulation of transcription from RNA polymerase II promoter (3 × 10-6)
			GO:0006333 [11]; chromatin (dis)assembly (4 × 10-10)
			GO:0003700 [10]; transcription factor activity (2 × 10-2)

(*) – The CB regions are sorted in decreasing order of abundance. They are denoted by their CB signatures in column #1. Column #2 contains the total number of members in a particular cluster; column #3 is the mean value of D, the disorder fraction of each member; column #4 lists the top five significantly-associated (P' ≤ 0.05) GO (Gene Ontology terms for the cluster in the format: GO term name [count for GO term]; description of GO term in words. In addition, bias types that are significantly associated with transcription (where we reduced GO categories to just two categories, 'transcription-related' and 'non-transcription-related'), are labelled with a † sign.