Table 4.
Bias | Number of members | Mean disorder (D) value |
Functional categories (GO term [# of occurrences]; description; P' value) |
{Q} † | 274 | 0.45 | GO:0005634 [78]; nucleus (2 × 10-14) |
GO:0006357 [53]; regulation of transcription from RNA polymerase II promoter (1 × 10-16) | |||
GO:0003700 [44]; transcription factor activity (3 × 10-12) | |||
GO:0003677 [37]; DNA binding (7 × 10-6) | |||
GO:0005515 [33]; protein binding (8 × 10-3) | |||
GO:0003704 [20]; specific RNA polymerase II transcription factor activity (2 × 10-5) | |||
{QH} † | 187 | 0.81 | GO:0005634 [75]; nucleus (2 × 10-24) |
GO:0003700 [52]; transcription factor activity (3 × 10-27) | |||
GO:0006357 [45]; regulation of transcription from RNA polymerase II promoter (9 × 10-18) | |||
GO:0008270 [36]; Zn-ion binding (9 × 10-12) | |||
GO:0003677 [35]; DNA binding (1 × 10-9) | |||
GO:0006355 [30]; DNA-dept. regulation of transcription (3 × 10-13) | |||
GO:0003702 [29]; RNA polymerase II transcription factor activity (4 × 10-16) | |||
GO:0045449 [26]; regulation of transcription (6 × 10-15) | |||
GO:0007498 [22]; mesoderm development (1 × 10-7) | |||
{C} | 70 | 0.00 | GO:0005198 [25]; structural molecule activity (2 × 10-27) |
GO:0007165 [23]; signal transduction (5 × 10-14) | |||
GO:0016337 [19]; cell-cell adhesion (1 × 10-19) | |||
GO:0005886 [14]; plasma membrane (1 × 10-3) | |||
GO:0005102 [14]; receptor binding (6 × 10-9) | |||
{P} | 62 | 0.13 | |
{T} | 61 | 0.28 | |
{N} | 58 | 0.45 | GO:0005634 [19]; nucleus (3 × 10-2) |
GO:0003729 [16]; mRNA binding (1 × 10-7) | |||
GO:0003723 [16]; RNA binding (1 × 10-11) | |||
{G} | 50 | 0.14 | |
{H} | 44 | 0.42 | |
{S} | 38 | 0.25 | |
{A} † | 38 | 0.21 | GO:0005634 [16] nucleus (3 × 10-3) |
GO:0006357 [14]; regulation of transcription from RNA polymerase II promoter (3 × 10-6) | |||
GO:0006333 [11]; chromatin (dis)assembly (4 × 10-10) | |||
GO:0003700 [10]; transcription factor activity (2 × 10-2) |
(*) – The CB regions are sorted in decreasing order of abundance. They are denoted by their CB signatures in column #1. Column #2 contains the total number of members in a particular cluster; column #3 is the mean value of D, the disorder fraction of each member; column #4 lists the top five significantly-associated (P' ≤ 0.05) GO (Gene Ontology terms for the cluster in the format: GO term name [count for GO term]; description of GO term in words. In addition, bias types that are significantly associated with transcription (where we reduced GO categories to just two categories, 'transcription-related' and 'non-transcription-related'), are labelled with a † sign.