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(A) Growth of M. tuberculosis in BACTEC 7H12B broth following exposure to increasing concentrations of rifampin. (B) Effect of increasing Cmax/MIC ratios on the bactericidal activity of rifampin on days 1 (r2 = 0.899), 5 (r2 = 0.963), 7 (r2 = 0.946), and 9 (r2 = 0.898) after the addition of drug. Each point represents the mean of duplicate values. The bactericidal effect is calculated on the basis of the initial inoculum prior to the addition of rifampin.
