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Comparison of the magnitude of AUC24/MIC for the bactericidal effect of rifampin in vitro (□), in infected macrophage monolayers (∗), or in vivo (•) following 4 to 6 days of exposure. AUC/MIC is defined as follows: (C × T)/MIC in broth for the in vitro and macrophage studies and AUC24/MIC in serum for the in vivo studies.
