TABLE 1.

Summary of statistics for garenoxacin pharmacokinetic parameters tabulated by dose group and day

Parameter and garenoxacin dose (mg)	Result fora:
	Day 1	Day 7	Day 14
Cmax, μg/ml [geometric mean (% CV)]
100	1.2 (23.2)	1.5 (23.1)	1.6 (37.0)
200	2.4 (15.2)	2.9 (15.9)	3.0 (9.2)
400	4.6 (14.8)	5.2 (15.8)	5.6 (17.6)
800	9.5 (12.8)	12.6 (32.2)	14.4 (40.4)
1,200	16.3 (31.8)	21.5 (37.9)	24.0 (34.8)
AUC∞, μg/ml [geometric mean (% CV)]
100	15.1 (24.4)	N/Ad	N/A
200	29.6 (20.4)	N/A	N/A
400	55.2 (18.5)	N/A	N/A
800	130.3 (16.5)	N/A	N/A
1,200	230.0 (33.1)	N/A	N/A
AUGτ,b μg/ml [geometric mean (% CV)]
100	11.5 (21.3)	15.6 (18.6)	15.7 (20.5)
200	23.3 (19.0)	31.0 (17.6)	32.7 (17.3)
400	45.2 (15.6)	58.5 (23.1)	58.6 (19.9)
800	100.7 (10.7)	157.9 (44.5)	180.8 (48.8)
1,200	179.8 (30.0)	271.0 (36.5)	307.3 (31.2)
t1/2, h [mean (SD)]
100	N/A	N/A	17.8 (3.3)
200	N/A	N/A	15.5 (4.4)
400	N/A	N/A	13.3 (2.2)
800	N/A	N/A	15.5 (4.0)
1,200	N/A	N/A	15.4 (3.4)
Tmax, h [median (minimum to maximum)]
100	1.25 (0.75-2.00)	1.13 (0.75-4.00)	1.13 (0.50-4.00)
200	1.75 (1.00-2.00)	1.50 (1.00-3.00)	1.75 (1.00-2.00)
400	1.75 (0.75-2.00)	1.25 (0.50-1.50)	1.50 (0.75-2.00)
800	1.75 (1.00-4.00)	1.50 (0.75-3.00)	2.50 (1.50-4.00)
1,200	2.50 (2.00-4.00)	2.50 (1.50-4.00)	2.00 (1.50-4.00)
MRT, h [mean (SD)]
100	16.9 (3.0)	18.8 (5.1)	19.4 (2.8)
200	15.6 (2.4)	16.0 (5.1)	18.2 (3.5)
400	13.9 (1.1)	15.6 (1.7)	17.1 (1.8)
800	16.0 (2.7)	20.0 (5.7)	21.2 (5.5)
1,200	16.0 (2.9)	17.3 (2.2)	20.4 (2.7)
% UR [mean (SD)]
100	37.3 (8.3)	50.7 (9.0)	52.0 (19.7)c
200	28.0 (6.4)	44.4 (6.0)	44.3 (13.1)
400	23.2 (7.7)	37.6 (9.8)	43.6 (3.2)
800	21.1 (3.5)c	36.6 (9.1)	33.1 (6.0)
1,200	25.4 (2.8)	36.5 (4.1)	40.9 (3.6)
CLR, ml/min [mean (SD)]
100	56.1 (19.9)	55.2 (15.2)	55.7 (11.7)
200	40.6 (11.5)	48.4 (11.5)	46.9 (18.5)
400	34.9 (13.2)	44.6 (17.1)	50.4 (11.0)
800	27.0 (5.6)	33.3 (17.8)	25.6 (10.0)
1,200	29.4 (10.1)	28.0 (8.5)	27.5 (8.2)

^an = 6 for all groups but the 400-mg dose group.

^bAUC_τ is 24 h.

^cn = 5.

^dN/A, not applicable.