Figure 1.

Alignment of sequences of five Prp18 proteins. S. cerevisiae Prp18Δ79 was aligned with the Prp18s of H. sapiens, D. melanogaster, A. thaliana, C. elegans, and S. pombe. Positions at which four or more sequences are identical are shown red on blue; positions at which three sequences are identical are shown red on cyan; and positions at which three or more sequences are similar are shown green on yellow. Similarities used are D≈E, K≈R, N≈Q, A≈G, C≈S≈T, V≈L≈I≈M, and F≈Y≈W. The positions of α-helices in the S. cerevisiae structure are indicated above the sequence. Loops 1 through 5, which precede helices 1 through 5, are indicated by red lines; broken lines identify regions where the protein was disordered in the crystal. The A. thaliana Prp18 extends 32 aa beyond the end shown here.