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A schematic drawing showing the proposed model of the Prp18 function in the second step of splicing. Pre-mRNA is shown in purple; exons 1 and 2 are indicated. Prp18 is shown in red and in contact with both Slu7 (green) and U5 snRNP (orange); the latter two contact the 3′ splice site directly. U2 (cyan) and U6 (black) snRNPs are shown to indicate their involvement in the second step splicing reaction.
