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Sharp differences in regenerative activity of collagen-based scaffolds that are matched closely in structure. The contraction half-life (inverse measure of contraction rate) of a skin wound model (guinea pig) is shown for several scaffolds with identical structure except pore diameter. The half-life reaches a maximum (corresponding to maximum regenerative activity) when the scaffold pore diameter is in the range 20–120 μm. Other scaffolds were inactive (Yannas et al. 1989).
