TABLE 2.
Nucleotide differences identified in rifampin-resistant isolates of C. trachomatis
| Variant | MIC (μg/ml) | Nucleotide change | Corresponding position in E. coli gene | Location (cluster)a | No. of clones |
|---|---|---|---|---|---|
| 1 | 4 | GCA→GTA (Ala467→Val) | 522 | I | 1 |
| 2 | 4 | GCA→GTA (Ala467→Val) | 522 | I | 1 |
| 3 | 4 | GCA→GTA (Ala467→Val) | 522 | I | 8 |
| 4 | 64 | CAC→TAC (His471→Tyr) | 526 | I | 13 |
| 64 | CAC→TAC (His471→Tyr) | 526 | I | 1 | |
| CCT→TCT (Pro535→Ser) | 590 | DS of II | |||
| 64 | CAC→TAC (His471→Tyr) | 526 | I | 1 | |
| CGA→CAA (Arg395→Gln) | 450 | US of I | |||
| 64 | CAC→TAC (His471→Tyr) | 526 | I | 1 | |
| ATT→ATA (517 silent) | 572 | II | |||
| 64 | CAC→TAC (His471→Tyr) | 526 | I | 1 | |
| GCA→ACA (Ala497→Thr) | 552 | I-II | |||
| 5 | 256 | CAC→TAC (His471→Tyr) | 526 | I | 14 |
| 256 | CAC→TAC (His471→Tyr) | 526 | I | 1 | |
| AAA→GAA (Lys584→Glu) | 639 | DS of II | |||
| 256 | CAC→TAC (His471→Tyr) | 526 | I | 1 | |
| GCA→GCC (392 silent) | 447 | US of I | |||
| 256 | CAC→TAC (His471→Tyr) | 526 | I | 1 | |
| GAC→GGC (Asp494→Gly) | 549 | I-II |
a
DS, downstream; US, upstream.