FIG. 3.

Amino acid comparison of PBP 1A encoded by pbp-1A genes from H. pylori ATCC 700392, its transformed resistant H. pylori strain with genomic DNA extracted from clinical resistant H. pylori IH-1, and clinical resistant H. pylori IH-1. Amino acid sequences beginning from position 320 correspond to the nucleotide sequence switch of pbp-1A shown in Fig. 2 (shaded amino acid sequences). Amino acid sequence signature motifs of PBP 1A based on the report by Harris et al. (20) are shown in boldface type with underlining.