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. 2004 Aug;165(2):357–371. doi: 10.1016/s0002-9440(10)63303-2

Figure 6.

Figure 6

Representative double-immunofluorescence photomicrographs demonstrating co-accumulations of proteins in damaged axons (A–L), neurons (M–N) and macrophages (O–P) at 3 days and 6 months post-injury. Merged green and red fluorescence shown in yellow. In axon bulbs in the white matter, co-accumulation Aβ (antibodies 6F3D and 13335/Green) was found with CCA (249/Red) in (A) and (F), caspase-3 (P20/Red) in (B), BACE (BACE-2/Red) in (G), APP (22C11/Red) in (E), and PS-1 (PS-1/Red) in (H). Co-accumulation of BACE (Green) was found with APP (Red) in (C) and (I), kinesin (L1/Red) in (D) and (K), and CCA (Red) in (J). Co-accumulation of APP (Red) was found with PS-1 (Green) in (L). In neurons, Aβ (Green) co-accumulated with APP (Red) in (M) and CCA (Red) in (N). Macrophages demonstrated co-immunoreactivity of Aβ (13335/Green) with OX42 (CD11b/Red) in (O) and (P). Bar, 25 μm.