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. 2004 Sep;165(3):719–728. doi: 10.1016/s0002-9440(10)63335-4

Figure 8.

Figure 8

Mild GSH depletion does not impair myogenesis. Differentiating C2C12 cells were treated with DEM at the doses shown at day 1 for 15 minutes and then BSO was added as indicated in Figure 3. A: GSH levels were examined in differentiating cells at day 2 and 7 as indicated in Figure 1B. B: NF-κB activation was examined in nuclear extracts from cells pretreated with DEM at the doses indicated. The effect of mild GSH depletion on differentiation was examined by CK activity (C) as well as expression of MyHC with respect to α-tubulin (D).