Figure 7.

Ang-1-induced angiogenic events are reversible. a: Western blot analyses done on ST and DT mice before Dox exposure demonstrated the presence of transgenic Ang-1 in the DT mouse liver. After exposure to Dox (+Dox), transgenic Ang-1 production was suppressed. Three individual samples are shown (DT1 to DT3). b–d: Histological examination of DT mice having Ang-1 expression suppressed for 2 weeks with Dox returned the liver morphology back to normal with a uniform redistribution of veins. c and d: Histologically, normal portal tracts and normal hepatic veins without dilatation were observed in DT livers and the portal tracts contained veins, arteries, and ducts. e: Alternating regions of atrophic and nonatrophic hepatocytes were seen resembling the pattern of NRH, which may account for the mechanism of reversal. a, artery; d, duct; hv, hepatic vein; pv, portal vein; pt, portal tract. Scale bars: ∼65 μm (b and d); ∼33 μm (c).