Figure 8.

Suppressing Ang-1 production during development and subsequent exposure to excess Ang-1 in adulthood leads to moderate levels of vascular remodeling. a and e: Mice exposed to Dox throughout gestation and into adulthood show no production of Ang-1 (as indicated by LacZ staining) and have completely normal looking livers. Transgenic Ang-1 production returns (as indicated by LacZ staining) 4 weeks (b, f), 8 weeks (c, g), and 14 weeks (d, h) after the removal of Dox exposure. Mild to moderate changes in the vasculature are observed at the edges of the liver as evidenced by moderate increases in vessel visibility and vessel size. No gross changes in vessel reorganization in the subcapsular space were seen in any of the DT livers.