Disruption of SR-BI in bone marrow-derived cells inhibits atherosclerotic lesion development in WT mice. a: Formation of atherosclerotic lesions was determined at the aortic root of SR-BI+/+ → WT and SR-BI−/− → WT chimeras that were fed a high-cholesterol/cholate diet (1% cholesterol, 15% fat, 0.5% cholate) for 10 weeks. b: The mean lesion area was calculated from oil red O-stained cross-sections of the aortic root at the level of the tricuspid valves. Values represent the mean ± SEM of at least seven mice. *, Statistically significant difference of P < 0.01, as compared to SR-BI+/+ → WT. Original magnifications, ×100.