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Histological demonstration of marked cartilage destruction in Tg rabbits at 35 days. Micrographs of sections from the joints of carrageenan-injected Tg rabbits stained with H&E (left), safranin O (middle), and Masson’s trichrome (right) show that there was cartilage degeneration and necrosis (top) or erosion (bottom), associated with the loss of safranin O and Masson’s trichrome staining in the articular surface.
