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. 2004 Oct;165(4):1129–1139. doi: 10.1016/S0002-9440(10)63374-3

Figure 5-4244.

Figure 5-4244

Effect of tPA null mutation on survival of Ela1-myc transgenic mice. Survival of Ela1-myc wild-type transgenic mice versus Ela1-myc:tPA+/− (A) or Ela1-myc:tPA−/− (B) is compared. C: Survival curve of Ela1-myc:tPA+/− mice versus Ela1-myc:tPA−/−. Of note, there is a statistically significant increase in survival of Ela1-myc tPA−/− mice (P = 0.02 when compared to Ela1-myc or P = 0.005 when compared to Ela1-myc:tPA+/−) which depends on effects taking place after 120 days of follow-up, when acinar-to-ductal metaplasia and tPA expression occur in these tumors.