Table 3.

Analysis of Markers of Angiogenesis and Cell Proliferation in Tumors from Ela1-myc and Ela1-myc:tPA−/− Mice

Histology	von Willebrand factor*			Ki-67*
	Ela1-myc	Ela1-myc: tPA−/−	p†	Ela1-myc	Ela1-myc: tPA−/−	p†
Ductal + mixed/ductal	14.5 ± 3.1 (11)‡	12.1 ± 2.3 (9)	0.04	33.4 ± 12.5 (5)	22.3 ± 14.3 (4)	0.29
Acinar + mixed/acinar	8.1 ± 4.2 (13)	6.3 ± 2.8 (10)	0.28	37.9 ± 21.8 (6)	30.7 ± 19.1 (6)	0.31

^*, vWF, results expressed as vessels/field; Ki-67, results expressed as % immunoreactive cells (mean ± standard deviation).

^†, p values correspond to the comparison of data from tPA+/+ and tPA−/− mice for a given parameter using Mann-Whitney test.

^‡, brackets indicate the total number of tumors analyzed.