Figure 4-4263.

Accelerated Aβ peptide deposition in APP^SLPS1KI mouse brain. Representative photomicrographs of Aβ immunostaining on sagittal brain sections taken from 6 (A)- and 10 (B)-month-old APP^SL (left) and APP^SLPS1KI mice (right) (4G8 antibody on 25-μm-thick cryostat sections). Aβ immunostaining in the entire section and in the cortical (Cx), subicular, hippocampal (Hip), and thalamic (Tha) subareas illustrate the acceleration of extracellular Aβ deposition and its widespread distribution in brain parenchyma of young (ie, 6 months of age) APP^SLPS1KI mice (higher magnification in bottom panels). Note the difference in the size and number of Aβ deposits in double- versus single-transgenic mice at 10 months of age with overall similar amyloid load (B). Scale bars: 500 μm, top panel (A); 20 μm, middle panel (A); 20 μm, bottom panel (B).