Table 3.

Relationship of Cdt1-Cdc6/p53 Patterns with Growth (GI) Index, Its Components Proliferation (PI) and Apoptotic (AI) Indices, and Ploidy Status of the Tumors

Pattern	(No. of cases)	GI = PI/AI mean value (%) [informative cases]	P	PI mean value (%) [informative cases]	P	AI median value (%) [informative cases]	P	Ploidy status aneuploidy¶	P
“normal” hCdt1-hCdc6/p53wt	(9)	12.4 ± 7.8 [8]		33.3 ± 9.4 [8]		2.9 [8]		6/9 (66%)
“deregulated” hCdt1-hCdc6/p53wt	(18)	11.2 ± 8.4 [17]		24.4 ± 8.4 [17]		3.1 [17]		5/18 (28%)
“normal” hCdt1-hCdc6/p53mt	(16)	33.0 ± 30.7 [15]	0.006*	33.8 ± 13.7 [15]	0.006*	1.25 [15]	0.013‡	9/16 (56%)	0.034∥
“deregulated” hCdt1-hCdc6/p53mt	(24)	57.2 ± 63.2 [24]		38.1 ± 12.9 [24]		0.9 [24]		16/22 (73%)
“deregulated” hCdt1-hCdc6/p53wt	(18)		0.008†		0.003†		0.001§		0.005∥
“deregulated” hCdt1-hCdc6/p53mt	(24)
“normal” hCdt1-hCdc6/p53wt	(9)		1.000†		0.923†		0.003§		0.470∥
“normal” hCdt1-hCdc6/p53mt	(16)

^*ANOVA.

^†Bonferroni test.

^‡Kruskal-Wallis test.

^§Mann-Whitney test.

^¶Aneuploid cases/total informative cases.

^∥Pearson chi-square test.

wt, Wild-type; mt, mutant.