Figure 6-4247.

Effects of anti-CCL17 and anti-CCL22 antibodies on the size (top) and eosinophil cellularity (bottom) of secondary granulomas at days 4 and 8 after egg infusion into S. mansoni-sensitized mice. Mice received IgG, anti-CCL17 antibody, or anti-CCL22 antibody by intraperitoneal injection beginning immediately after intravenous S. mansoni egg infusion and every other day thereafter. Data are mean ± SEM of n = 5 per group. **, P ≤ 0.01; ***, P ≤ 0.001 compared with granuloma size or eosinophil counts in egg granulomas in S. mansoni-sensitized mice infused with S. mansoni eggs and treated with IgG.