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. 2004 Nov;165(5):1519–1533. doi: 10.1016/S0002-9440(10)63410-4

Figure 4.

Figure 4

A representative experiment showing clinical outcomes after injecting two IFN-γ-secreting T-cell lines (8-4.G6 and 6-G.10) and two GKO lines (X2.502 and line 3) into either BALB-GKO or BALB-CXCR2 KO recipients. Each T-cell line was activated in vitro, then injected in parallel into recipient groups of five mice each. Clinical scores were assigned as described in Materials and Methods. Both IFN-γ-secreting clones, shown at left, induced essentially identical disease with similar kinetics in either GKO or CXCR2 KO recipient mice. GKO clone X2.502 (derived from line 1), was also able to induce EAE with essentially the same kinetics and severity whether or not recipients expressed CXCR2. In contrast, GKO-derived line 3 is critically dependent on neutrophil recruitment to effect clinical disease.