Figure 1.

A: Sample from day 3 showing an ulcer defect (left) filled by crust, with a mixed underlying inflammatory infiltrate. The epidermis adjacent to the ulcer exhibits acanthosis and reactive enlargement of keratinocytes. B: Sample from day 5 exhibiting greater organization of fibrin at the surface of the ulcer, diminished crust, and growth of epidermis over the edge of the ulcer. C: Sample from day 14 showing complete re-epithelialization. The epidermis over the scar (right) exhibits acanthosis, hypergranulosis, and hyperkeratosis. Fibrin has been replaced by horizontally oriented collagen bundles, interspersed by plump fibroblasts.