Table 1.
Case Information for Synaptosome Samples
| No. | Sex | Age (years) | PMI (hours) | MMSE | Frontal Atrophy | Frontal Plaques | Amyloid fluor. in terminals (RFU) |
|---|---|---|---|---|---|---|---|
| Controls | |||||||
| 1 | F | 84 | 6 | 27 | None | None | 18.05 |
| 2 | F | 91 | 4.4 | 29 | Mod | Mod | 25.95 |
| 3 | M | 69 | 6.25 | 28 | Mild | None | 19.93 |
| 4 | M | 90 | 10.75 | 27 | None | None | 18.21 |
| 5 | F | 91 | 9 | – | Mild | Sparse | 13.45 |
| 6 | F | 92 | 7 | 25 | None | None | 16.46 |
| 7 (Parkinson’s) | F | 83 | 5.17 | 12 | Mod | Sparse | 50.9 |
| 8 (Parkinson’s) | M | 79 | 3.3 | – | Mild | Sparse | 25.43 |
| Alzheimer’s cases | |||||||
| 1 | F | 77 | 4.25 | 7 | Mod | Mod | 40.25 |
| 2 | F | 86 | 6 | 6 | Mild | Mod | – |
| 3 | M | 83 | 4 | – | Mild | Mod | 46.1 |
| 4 | F | 81 | 3.7 | – | Mod | Mod | 49.65 |
| 5 | F | 78 | 4.5 | – | Mod | Mod | 24.58 |
| 6 | F | 90 | 3.28 | 15 | Mild | Freq | 30.29 |
| 7 | F | 80 | 3.4 | 0 | Severe | Freq | 67.88 |
| 8 | M | 85 | 4.3 | 5 | Mod | Mod | 95.27 |
| 9 | M | 66 | 5 | 1 | Mild | Mod | 69.96 |
| 10 | F | 85 | 3.7 | – | Severe | Mod | 82.08 |
Plaque level refers to thioflavin-positive mature neuritic plaques with core; sparse (<5/field), mod (6 to 20/field), freq (21 to 30/field, or above). RFU, relative fluorescence units for 10G4 antibody fluorescence measured by flow cytometry.